1, 2 Currently, pulmonary endarterectomy (PEA) is the only potentially curative treatment option resulting in improved functional status, hemodynamics, and overall survival. In post‐ PEA patients, sildenafil did not affect resting hemodynamics nor right ventricular function, but decreased the mPAP/cardiac output slope and increased peak exercise right ventricular ejection fraction.Ĭhronic thromboembolic pulmonary hypertension (CTEPH) is a serious complication of pulmonary embolism, occurring in 0.1% to 4% of patients surviving an episode of acute pulmonary embolism. Nevertheless, resting pulmonary arterial compliance values in CTEPH and post‐ PEA patients were even lower than those in controls at peak exercise. Exercise led to reduction of pulmonary arterial compliance in all groups. In contrast, peak exercise right ventricular ejection fraction was reduced both in post‐ PEA and CTEPH patients. Relative to controls, resting right ventricular ejection fraction was reduced in CTEPH, but not in post‐ PEA patients. The mPAP–cardiac output slope was steeper in post‐ PEA patients than in controls and similar to CTEPH. Peak oxygen consumption and peak heart rate were significantly reduced in post‐ PEA and CTEPH patients compared to controls. Stroke: Vascular and Interventional Neurologyįourteen healthy controls, 15 CTEPH patients, and 7 patients with normalized resting mPAP (≤25 mm Hg) post‐ PEA underwent cardiopulmonary exercise testing, followed by cardiac magnetic resonance imaging with simultaneous invasive mPAP measurement during incremental supine cycling exercise.Journal of the American Heart Association (JAHA).
Arteriosclerosis, Thrombosis, and Vascular Biology (ATVB).
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